InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mesp1

Summary

InnateDB Protein

IDBP-194336.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mesp1

Protein Name

mesoderm posterior 1

Synonyms

bHLHc5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032760

InnateDB Gene

IDBG-194334 (Mesp1)

Protein Structure

UniProt Annotation

Function

Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways. {ECO:0000269PubMed:15677726, ECO:0000269PubMed:17306789}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

No expression was detected in adult tissues except the testis. Expression in the testis was regulated developmentally; expressed 2 weeks after birth, and increases, reaching the full expression level in mature testes. {ECO:0000269PubMed:8787751}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0035326	enhancer binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001947	heart looping
GO:0003007	heart morphogenesis
GO:0003139	secondary heart field specification
GO:0003143	embryonic heart tube morphogenesis
GO:0003210	cardiac atrium formation
GO:0003211	cardiac ventricle formation
GO:0003236	sinus venosus morphogenesis
GO:0003241	growth involved in heart morphogenesis
GO:0003259	cardioblast anterior-lateral migration
GO:0003260	cardioblast migration
GO:0006351	transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0007369	gastrulation
GO:0008078	mesodermal cell migration
GO:0022008	neurogenesis
GO:0023019	signal transduction involved in regulation of gene expression
GO:0035481	positive regulation of Notch signaling pathway involved in heart induction
GO:0042662	negative regulation of mesodermal cell fate specification
GO:0042664	negative regulation of endodermal cell fate specification
GO:0045446	endothelial cell differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048368	lateral mesoderm development
GO:0051155	positive regulation of striated muscle cell differentiation
GO:0055007	cardiac muscle cell differentiation
GO:0060913	cardiac cell fate determination
GO:0060921	sinoatrial node cell differentiation
GO:0060947	cardiac vascular smooth muscle cell differentiation
GO:0060975	cardioblast migration to the midline involved in heart field formation
GO:0070368	positive regulation of hepatocyte differentiation
GO:0090082	positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:107785

InterPro

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

PFAM

PF00010

PRINTS

PIRSF

SMART

SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97309

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

17292

UniGene

RefSeq

NP_032614

MGI ID

MGI Symbol

Mesp1

OMIM

CCDS

CCDS21387

HPRD

IMGT

EMBL

BC125505 BC125507 D83674

GenPept

AAI25506 AAI25508 BAA12041