Mus musculus Protein: Topbp1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-194376.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Topbp1 | ||||||||||||||||||||||
Protein Name | topoisomerase (DNA) II binding protein 1 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000035164 | ||||||||||||||||||||||
InnateDB Gene | IDBG-194374 (Topbp1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double- stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1- responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (By similarity). May play a role in spermatogenesis. {ECO:0000250, ECO:0000269PubMed:14718568}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner (By similarity). Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase. {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Highly expressed in testis. {ECO:0000269PubMed:15138768}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:1920018 | ||||||||||||||||||||||
InterPro |
IPR001357
BRCT domain IPR016126 Secretoglobin |
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PFAM |
PF00533
PF12738 PF01099 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00292
SM00096 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q6ZQF0 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q6ZQF0 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 235559 | ||||||||||||||||||||||
UniGene | Mm.413317 | ||||||||||||||||||||||
RefSeq | NP_795953 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Topbp1 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS23453 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AK084654 AK085031 AK129104 BC006707 BC007170 BC026608 BC049797 BC062111 | ||||||||||||||||||||||
GenPept | AAH06707 AAH07170 AAH26608 AAH49797 AAH62111 BAC39241 BAC39345 BAC97914 | ||||||||||||||||||||||