Version 5.4
Mus musculus Gene: Topbp1
Summary
InnateDB Gene IDBG-194374.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Topbp1
Gene Name topoisomerase (DNA) II binding protein 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032555
Encoded Proteins
IDBP-194376
topoisomerase (DNA) II binding protein 1
IDBP-788459
topoisomerase (DNA) II binding protein 1
IDBP-788461
topoisomerase (DNA) II binding protein 1
IDBP-788463
topoisomerase (DNA) II binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163781:
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:103305215-103350428
Strand Forward strand
Band F1
Transcripts
ENSMUST00000035164 ENSMUSP00000035164
ENSMUST00000189631
ENSMUST00000187065 ENSMUSP00000139773
ENSMUST00000186897
ENSMUST00000188840
ENSMUST00000185721 ENSMUSP00000140906
ENSMUST00000185305 ENSMUSP00000140862
ENSMUST00000190712
ENSMUST00000189349
ENSMUST00000185972
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007131 reciprocal meiotic recombination
GO:0010212 response to ionizing radiation
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0000922 spindle pole
GO:0001673 male germ cell nucleus
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005886 plasma membrane
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163781
View Gene Order
ENSBTAG00000000526
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
e2f_pathway
E2F transcription factor network
bard1pathway
BARD1 signaling events
atr_pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 235559
UniGene
RefSeq NM_176979 XM_006511705 XM_006511707
OMIM
CCDS CCDS23453
HPRD
IMGT
MGI ID MGI:1920018
MGI Symbol Topbp1
EMBL
GenPept
RNA Seq Atlas 235559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca