InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hadh

Summary

InnateDB Protein

IDBP-194387.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hadh

Protein Name

hydroxyacyl-Coenzyme A dehydrogenase

Synonyms

AA409008; AU019341; AW742602; Hadhsc; HCDH; Schad;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029610

InnateDB Gene

IDBG-194385 (Hadh)

Protein Structure

UniProt Annotation

Function

Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050660	flavin adenine dinucleotide binding
GO:0051287	NAD binding
GO:0070403	NAD+ binding

Biological Process

GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0009725	response to hormone
GO:0014823	response to activity
GO:0032868	response to insulin
GO:0042493	response to drug
GO:0046168	glycerol-3-phosphate catabolic process
GO:0046676	negative regulation of insulin secretion
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:96009

InterPro

IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR006076 FAD dependent oxidoreductase
IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding
IPR007698 Alanine dehydrogenase/PNT, NAD(H)-binding domain
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal

PFAM

PF00070
PF01266
PF00725
PF02737
PF01262
PF01210

PRINTS

PIRSF

SMART

SM01002

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61425