InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAS2R8

Summary

InnateDB Protein

IDBP-19443.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAS2R8

Protein Name

taste receptor, type 2, member 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000240615

InnateDB Gene

IDBG-19441 (TAS2R8)

Protein Structure

UniProt Annotation

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008527	taste receptor activity
GO:0033038	bitter taste receptor activity

Biological Process

GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186	G-protein coupled receptor signaling pathway
GO:0050909	sensory perception of taste