InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp1r8

Summary

InnateDB Protein

IDBP-194442.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp1r8

Protein Name

protein phosphatase 1, regulatory (inhibitor) subunit 8

Synonyms

6330548N22Rik; AU044684; NIPP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030702

InnateDB Gene

IDBG-194440 (Ppp1r8)

Protein Structure

UniProt Annotation

Function

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Essential for cell proliferation and early embryonic development. {ECO:0000269PubMed:15199142, ECO:0000269PubMed:15501817}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Mainly, but not exclusively, nuclear.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0004864	protein phosphatase inhibitor activity
GO:0005515	protein binding
GO:0008599	protein phosphatase type 1 regulator activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0007275	multicellular organismal development
GO:0008283	cell proliferation
GO:0008380	RNA splicing
GO:0043086	negative regulation of catalytic activity
GO:0050790	regulation of catalytic activity