Version 5.4
Mus musculus Gene: Ppp1r8
Summary
InnateDB Gene IDBG-194440.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp1r8
Gene Name protein phosphatase 1, regulatory (inhibitor) subunit 8
Synonyms 6330548N22Rik; AU044684; NIPP1
Species Mus musculus
Ensembl Gene ENSMUSG00000028882
Encoded Proteins
IDBP-194442
protein phosphatase 1, regulatory (inhibitor) subunit 8
IDBP-269853
protein phosphatase 1, regulatory (inhibitor) subunit 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117751:
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:132826929-132843169
Strand Reverse strand
Band D2.3
Transcripts
ENSMUST00000030702 ENSMUSP00000030702
ENSMUST00000105919 ENSMUSP00000101539
ENSMUST00000156777
ENSMUST00000131725
ENSMUST00000148228
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004864 protein phosphatase inhibitor activity
GO:0005515 protein binding
GO:0008599 protein phosphatase type 1 regulator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
GO:0008380 RNA splicing
GO:0043086 negative regulation of catalytic activity
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117751
View Gene Order
ENSBTAG00000003866
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.105230 Mm.309754
RefSeq NM_001290725 NM_146154 XM_006538464 XM_006538465 XM_006538466
OMIM
CCDS CCDS18736 CCDS71482
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca