Version 5.4
Mus musculus Protein: Kif5a
Summary
InnateDB Protein IDBP-194574.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kif5a
Protein Name kinesin family member 5A
Synonyms D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086;
Species Mus musculus
Ensembl Protein ENSMUSP00000096775
InnateDB Gene IDBG-194572 (Kif5a)
Protein Structure
UniProt Annotation
Function Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). {ECO:0000269PubMed:12682084}.
Subcellular Localization Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement
GO:0008152 metabolic process
Cellular Component
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:109564
InterPro IPR001752 Kinesin, motor domain
IPR009053 Prefoldin
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00225
PRINTS PR00380
PIRSF
SMART SM00129
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P33175
PhosphoSite PhosphoSite-P33175
TrEMBL Q3US62
UniProt Splice Variant
Entrez Gene 16572
UniGene Mm.470330
RefSeq NP_032473
MGI ID
MGI Symbol Kif5a
OMIM
CCDS CCDS24233
HPRD
IMGT
EMBL AF067179 AK140769 AK147352 AK147660 AK147707 AK220479 BC058396
GenPept AAC79803 AAH58396 BAD90503 BAE24473 BAE27862 BAE28054 BAE28087

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca