InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kif5a

Summary

InnateDB Gene

IDBG-194572.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kif5a

Gene Name

kinesin family member 5A

Synonyms

D10Bwg0738e; Khc; Kif5; Kns; mKIAA4086

Species

Mus musculus

Ensembl Gene

ENSMUSG00000074657

Encoded Proteins

kinesin family member 5A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155980:
This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:127225696-127263363

Strand

Reverse strand

Band

D3

Transcripts

ENSMUST00000099172

ENSMUSP00000096775

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0007018	microtubule-based movement
GO:0008152	metabolic process

Cellular Component

GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000155980

View Gene Order

ENSBTAG00000021336

Not yet available

Pathways

NETPATH

REACTOME

Hemostasis pathway

Immune System pathway

Kinesins pathway

Factors involved in megakaryocyte development and platelet production pathway

MHC class II antigen presentation pathway

Adaptive Immune System pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

MHC class II antigen presentation pathway

Kinesins pathway

Factors involved in megakaryocyte development and platelet production pathway

Insulin processing pathway

Metabolism of proteins pathway

Adaptive Immune System pathway

Immune System pathway

Peptide hormone metabolism pathway

Hemostasis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P33175

TrEMBL

Q3US62

UniProt Splice Variant

Entrez Gene

UniGene

Mm.30355 Mm.470330

RefSeq

NM_001039000 NM_008447 XM_006513274

OMIM

CCDS

CCDS24233

HPRD

IMGT

MGI ID

MGI:109564

MGI Symbol

Kif5a

EMBL

AF067179 AK140769 AK147352 AK147660 AK147707 AK220479 BC058396

GenPept

AAC79803 AAH58396 BAD90503 BAE24473 BAE27862 BAE28054 BAE28087

RNA Seq Atlas

16572

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca