InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hspb8

Summary

InnateDB Protein

IDBP-194613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspb8

Protein Name

heat shock protein 8

Synonyms

AU018630; AW413033; Cryac; D5Ucla4; E2IG1; H11; H11K; HSP20-like; HSP22;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037007

InnateDB Gene

IDBG-194611 (Hspb8)

Protein Structure

UniProt Annotation

Function

Displays temperature-dependent chaperone activity.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to nuclear foci during heat shock. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle, heart, uterus, liver, lung and ovary. Low levels found in stomach and brain. Not detected in small intestine, large intestine, kidney, spleen and testis. In the ovary, expression is concentrated in the endometrium and in the connective tissue between the circular and longitudinal muscles of the myometrium. {ECO:0000269PubMed:11133685}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0006950

response to stress

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:2135756

InterPro

IPR001436 Alpha crystallin/Heat shock protein
IPR002068 Alpha crystallin/Hsp20 domain
IPR008978 HSP20-like chaperone

PFAM

PF00011

PRINTS

PR00299

PIRSF

PIRSF036514

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JK92

PhosphoSite

PhosphoSite-Q9JK92

TrEMBL

UniProt Splice Variant

Entrez Gene

80888

UniGene

Mm.21549

RefSeq

NP_109629

MGI ID

MGI Symbol

Hspb8

OMIM

CCDS

CCDS19600

HPRD

IMGT

EMBL

AF250139 AF273453 AK005052 BC011219

GenPept

AAF65563 AAG00233 AAH11219 BAB23778