InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pld2

Summary

InnateDB Protein

IDBP-194657.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pld2

Protein Name

phospholipase D2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018429

InnateDB Gene

IDBG-194655 (Pld2)

Protein Structure

UniProt Annotation

Function

May have a role in signal-induced cytoskeletal regulation and/or endocytosis.

Subcellular Localization

Membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous. Highest levels in brain and lung. {ECO:0000269PubMed:9307024}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004630	phospholipase D activity
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding
GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity

Biological Process

GO:0002031	G-protein coupled receptor internalization
GO:0006898	receptor-mediated endocytosis
GO:0008152	metabolic process
GO:0016042	lipid catabolic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0031526	brush border membrane

Protein Structure and Domains

PDB ID

MGI:892877

InterPro

IPR001683 Phox homologous domain
IPR001736 Phospholipase D/Transphosphatidylase
IPR001849 Pleckstrin homology domain
IPR016555 Phospholipase D, eukaryota

PFAM

PF00787
PF00614
PF00169

PRINTS

PIRSF

PIRSF009376

SMART

SM00312
SM00155
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt