InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grin2b

Summary

InnateDB Protein

IDBP-194674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grin2b

Protein Name

glutamate receptor, ionotropic, NMDA2B (epsilon 2)

Synonyms

AW490526; GluN2B; Nmdar2b; NR2B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062284

InnateDB Gene

IDBG-194672 (Grin2b)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	78 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0016594	glycine binding

Biological Process

GO:0001662	behavioral fear response
GO:0001701	in utero embryonic development
GO:0001964	startle response
GO:0001967	suckling behavior
GO:0006810	transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0007268	synaptic transmission
GO:0007423	sensory organ development
GO:0007612	learning
GO:0007613	memory
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042596	fear response
GO:0045471	response to ethanol
GO:0048167	regulation of synaptic plasticity
GO:0048266	behavioral response to pain
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
GO:0060078	regulation of postsynaptic membrane potential
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0008021	synaptic vesicle
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0097481	neuronal postsynaptic density

Protein Structure and Domains

PDB ID

MGI:95821

InterPro

IPR001320 Ionotropic glutamate receptor
IPR001508 NMDA receptor
IPR001638 Extracellular solute-binding protein, family 3
IPR001828 Extracellular ligand-binding receptor
IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
IPR019594 Glutamate receptor, L-glutamate/glycine-binding
IPR028082 Periplasmic binding protein-like I

PFAM

PF00060
PF00497
PF01094
PF10565
PF10613

PRINTS

PR00177

PIRSF

SMART

SM00079
SM00062
SM00918

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt