InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Suds3

Summary

InnateDB Protein

IDBP-194703.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Suds3

Protein Name

suppressor of defective silencing 3 homolog (S. cerevisiae)

Synonyms

2400003N08Rik; 2410008L21Rik; AU067672; mSds3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083662

InnateDB Gene

IDBG-194701 (Suds3)

Protein Structure

UniProt Annotation

Function

Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in all newborn tissues tested, including brain, kidney and liver. {ECO:0000269PubMed:11909966}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0016575	histone deacetylation
GO:0043065	positive regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated