InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wasf2

Summary

InnateDB Protein

IDBP-194719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wasf2

Protein Name

WAS protein family, member 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081263

InnateDB Gene

IDBG-194715 (Wasf2)

Protein Structure

UniProt Annotation

Function

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0001525	angiogenesis
GO:0001667	ameboidal cell migration
GO:0006897	endocytosis
GO:0006928	cellular component movement
GO:0010592	positive regulation of lamellipodium assembly
GO:0016601	Rac protein signal transduction
GO:0030032	lamellipodium assembly
GO:0030036	actin cytoskeleton organization
GO:0030048	actin filament-based movement
GO:0035855	megakaryocyte development
GO:0051497	negative regulation of stress fiber assembly
GO:0072673	lamellipodium morphogenesis

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005769	early endosome
GO:0005856	cytoskeleton
GO:0005911	cell-cell junction
GO:0030027	lamellipodium
GO:0031209	SCAR complex
GO:0070062	extracellular vesicular exosome