InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SETD3

Summary

InnateDB Protein

IDBP-19472.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SETD3

Protein Name

SET domain containing 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000327436

InnateDB Gene

IDBG-19470 (SETD3)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0046975	histone methyltransferase activity (H3-K36 specific)

Biological Process

GO:0006351	transcription, DNA-templated
GO:0010452	histone H3-K36 methylation
GO:0018023	peptidyl-lysine trimethylation
GO:0018026	peptidyl-lysine monomethylation
GO:0018027	peptidyl-lysine dimethylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051149	positive regulation of muscle cell differentiation
GO:0051568	histone H3-K4 methylation