Version 5.4
Mus musculus Protein: Gcsh
Summary
InnateDB Protein IDBP-194725.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gcsh
Protein Name glycine cleavage system protein H (aminomethyl carrier)
Synonyms 1100001L02Rik; 5730591C18Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000037131
InnateDB Gene IDBG-194723 (Gcsh)
Protein Structure
UniProt Annotation
Function The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST) (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004047 aminomethyltransferase activity
GO:0019899 enzyme binding
Biological Process
GO:0006546 glycine catabolic process
GO:0019464 glycine decarboxylation via glycine cleavage system
GO:0032259 methylation
Cellular Component
GO:0005739 mitochondrion
GO:0005960 glycine cleavage complex
Protein Structure and Domains
PDB ID MGI:1915383
InterPro IPR002930 Glycine cleavage H-protein
IPR011053 Single hybrid motif
IPR017453 Glycine cleavage H-protein, subgroup
PFAM PF01597
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91WK5
PhosphoSite PhosphoSite-Q91WK5
TrEMBL Q9CV53
UniProt Splice Variant
Entrez Gene 68133
UniGene Mm.436956
RefSeq NP_080848
MGI ID 2EDG
MGI Symbol Gcsh
OMIM
CCDS CCDS22696
HPRD
IMGT
EMBL AC162858 AK003788 AK009543 AK019983 AK050373 BC014745 CH466525
GenPept AAH14745 BAB22996 BAB26349 BAB31951 BAC34217 EDL11574

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca