InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpr3

Summary

InnateDB Protein

IDBP-194762.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpr3

Protein Name

G-protein coupled receptor 3

Synonyms

Gpcr20; Gpcr21; Gpcr3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062083

InnateDB Gene

IDBG-194760 (Gpr3)

Protein Structure

UniProt Annotation

Function

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons (By similarity) and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes. {ECO:0000250, ECO:0000269PubMed:15956199, ECO:0000269PubMed:19259266}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in both the forebrain and hindbrain, with the highest level in habenula. Lower level expression in the testis. Highly expressed in regions. {ECO:0000269PubMed:19259266, ECO:0000269PubMed:8262253}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0040020	regulation of meiosis

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:101908

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000723 G protein-coupled receptor 3/6/12 orphan
IPR000984 G protein-coupled receptor 3
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00644
PR00648

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35413