InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Man2a1

Summary

InnateDB Protein

IDBP-194790.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Man2a1

Protein Name

mannosidase 2, alpha 1

Synonyms

Mana-2; Mana2; Map-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083928

InnateDB Gene

IDBG-194788 (Man2a1)

Protein Structure

UniProt Annotation

Function

Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Subcellular Localization

Golgi apparatus membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

All tissues, mostly in adrenal and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004559	alpha-mannosidase activity
GO:0004572	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
GO:0008270	zinc ion binding
GO:0015923	mannosidase activity
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0030246	carbohydrate binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0005975	carbohydrate metabolic process
GO:0006013	mannose metabolic process
GO:0006491	N-glycan processing
GO:0007005	mitochondrion organization
GO:0007033	vacuole organization
GO:0007585	respiratory gaseous exchange
GO:0048286	lung alveolus development
GO:0050769	positive regulation of neurogenesis
GO:0060042	retina morphogenesis in camera-type eye

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:104669

InterPro

IPR000602 Glycoside hydrolase family 38, N-terminal domain
IPR011013 Galactose mutarotase-like domain
IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
IPR011682 Glycosyl hydrolase family 38, C-terminal
IPR015341 Glycoside hydrolase, family 38, central domain
IPR028995 Glycoside hydrolase, families 57/38, central domain

PFAM

PF01074
PF07748
PF09261

PRINTS

PIRSF

SMART

SM00872

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P27046