InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Man2a1

Summary

InnateDB Gene

IDBG-194788.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Man2a1

Gene Name

mannosidase 2, alpha 1

Synonyms

Mana-2; Mana2; Map-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024085

Encoded Proteins

IDBP-194790

mannosidase 2, alpha 1

IDBP-627071

mannosidase 2, alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112893:
This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:64600736-64755110

Strand

Forward strand

Band

E1.1

Transcripts

ENSMUST00000086723	ENSMUSP00000083928
ENSMUST00000169239
ENSMUST00000169668	ENSMUSP00000130529

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004559	alpha-mannosidase activity
GO:0004572	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
GO:0008270	zinc ion binding
GO:0015923	mannosidase activity
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0030246	carbohydrate binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0005975	carbohydrate metabolic process
GO:0006013	mannose metabolic process
GO:0006491	N-glycan processing
GO:0007005	mitochondrion organization
GO:0007033	vacuole organization
GO:0007585	respiratory gaseous exchange
GO:0048286	lung alveolus development
GO:0050769	positive regulation of neurogenesis
GO:0060042	retina morphogenesis in camera-type eye

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome