InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dctn2

Summary

InnateDB Protein

IDBP-194793.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dctn2

Protein Name

dynactin 2

Synonyms

2310042E05Rik; C130077D06Rik; C87049; DCTN-50; GMP23-48K; p50; RBP50;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026479

InnateDB Gene

IDBG-194791 (Dctn2)

Protein Structure

UniProt Annotation

Function

Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. {ECO:0000269PubMed:14983524}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:14983524, ECO:0000269PubMed:9144527}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0030507	spectrin binding

Biological Process

GO:0007052	mitotic spindle organization
GO:0007067	mitotic nuclear division
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0032402	melanosome transport

Cellular Component

GO:0000776	kinetochore
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005869	dynactin complex
GO:0005874	microtubule
GO:0016020	membrane
GO:0030286	dynein complex
GO:0030426	growth cone
GO:0031982	vesicle
GO:0070062	extracellular vesicular exosome