InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dctn2

Summary

InnateDB Gene

IDBG-194791.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dctn2

Gene Name

dynactin 2

Synonyms

2310042E05Rik; C130077D06Rik; C87049; DCTN-50; GMP23-48K; p50; RBP50

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025410

Encoded Proteins

IDBP-194793

dynactin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175203:
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:127266262-127281959

Strand

Forward strand

Band

Transcripts

ENSMUST00000026479

ENSMUSP00000026479

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0030507	spectrin binding

Biological Process

GO:0007052	mitotic spindle organization
GO:0007067	mitotic nuclear division
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0032402	melanosome transport

Cellular Component

GO:0000776	kinetochore
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005869	dynactin complex
GO:0005874	microtubule
GO:0016020	membrane
GO:0030286	dynein complex
GO:0030426	growth cone
GO:0031982	vesicle
GO:0070062	extracellular vesicular exosome