InnateDB Protein
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IDBP-194827.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Eif3m
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Protein Name
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eukaryotic translation initiation factor 3, subunit M
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Synonyms
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Ga17; Pcid1; Tango7;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000028592
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InnateDB Gene
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IDBG-194825 (Eif3m)
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Protein Structure
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Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. {ECO:0000255HAMAP- Rule:MF_03012}.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03012}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
33 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
GO:0005852
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eukaryotic translation initiation factor 3 complex
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GO:0016282
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eukaryotic 43S preinitiation complex
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GO:0033290
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eukaryotic 48S preinitiation complex
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GO:0071541
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eukaryotic translation initiation factor 3 complex, eIF3m
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PDB ID |
MGI:1351744
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InterPro |
IPR000717
Proteasome component (PCI) domain
IPR016024
Armadillo-type fold
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PFAM |
PF01399
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PRINTS |
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PIRSF |
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SMART |
SM00088
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TIGRFAMs |
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Modification |
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SwissProt |
Q99JX4
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PhosphoSite |
PhosphoSite-Q99JX4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
98221
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UniGene |
Mm.379278
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RefSeq |
NP_663355
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MGI ID |
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MGI Symbol |
Eif3m
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OMIM |
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CCDS |
CCDS16495
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HPRD |
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IMGT |
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EMBL |
AK077480
AK084738
AK146222
AK168066
AL606494
BC005598
BC089568
BC103795
BC116787
BC116789
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GenPept |
AAH05598
AAH89568
AAI03796
AAI16788
AAI16790
BAC36821
BAC39270
BAE26990
BAE40042
CAM17236
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