InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nos1

Summary

InnateDB Protein

IDBP-194928.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Nos1

Protein Name

nitric oxide synthase 1, neuronal

Synonyms

2310005C01Rik; bNOS; nNOS; NO; Nos-1; NOS-I;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099617

InnateDB Gene

IDBG-194926 (Nos1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003958	NADPH-hemoprotein reductase activity
GO:0004517	nitric-oxide synthase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0001666	response to hypoxia
GO:0002028	regulation of sodium ion transport
GO:0006809	nitric oxide biosynthetic process
GO:0006941	striated muscle contraction
GO:0007263	nitric oxide mediated signal transduction
GO:0009408	response to heat
GO:0018119	peptidyl-cysteine S-nitrosylation
GO:0031284	positive regulation of guanylate cyclase activity
GO:0033555	multicellular organismal response to stress
GO:0042738	exogenous drug catabolic process
GO:0043267	negative regulation of potassium ion transport
GO:0045776	negative regulation of blood pressure
GO:0045909	positive regulation of vasodilation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051346	negative regulation of hydrolase activity
GO:0051926	negative regulation of calcium ion transport
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016529	sarcoplasmic reticulum
GO:0042383	sarcolemma
GO:0045121	membrane raft
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:97360

InterPro

IPR001094 Flavodoxin
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001478 PDZ domain
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR003097 FAD-binding, type 1
IPR004030 Nitric oxide synthase, oxygenase domain
IPR008254 Flavodoxin/nitric oxide synthase
IPR012144 Nitric-oxide synthase, eukaryote
IPR017938 Riboflavin synthase-like beta-barrel
IPR029039 Flavoprotein-like

PFAM

PF00175
PF00595
PF13180
PF00667
PF02898
PF00258

PRINTS

PR00369
PR00371

PIRSF

PIRSF000333

SMART

SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References