InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nos1

Summary

InnateDB Gene

IDBG-194926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nos1

Gene Name

nitric oxide synthase 1, neuronal

Synonyms

2310005C01Rik; bNOS; nNOS; NO; Nos-1; NOS-I

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029361

Encoded Proteins

IDBP-194928

nitric oxide synthase 1, neuronal

IDBP-790255

nitric oxide synthase 1, neuronal

IDBP-790254

nitric oxide synthase 1, neuronal

IDBP-540207

nitric oxide synthase 1, neuronal

IDBP-624385

nitric oxide synthase 1, neuronal

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089250:
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5\' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:117781032-117958840

Strand

Forward strand

Band

Transcripts

ENSMUST00000102557	ENSMUSP00000099617
ENSMUST00000086451	ENSMUSP00000138506
ENSMUST00000138579	ENSMUSP00000138176
ENSMUST00000124194
ENSMUST00000142742	ENSMUSP00000120421
ENSMUST00000138554
ENSMUST00000171055	ENSMUSP00000127432

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003958	NADPH-hemoprotein reductase activity
GO:0004517	nitric-oxide synthase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0001666	response to hypoxia
GO:0002028	regulation of sodium ion transport
GO:0006809	nitric oxide biosynthetic process
GO:0006941	striated muscle contraction
GO:0007263	nitric oxide mediated signal transduction
GO:0009408	response to heat
GO:0018119	peptidyl-cysteine S-nitrosylation
GO:0031284	positive regulation of guanylate cyclase activity
GO:0033555	multicellular organismal response to stress
GO:0035066	positive regulation of histone acetylation
GO:0042738	exogenous drug catabolic process
GO:0043267	negative regulation of potassium ion transport
GO:0045776	negative regulation of blood pressure
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045909	positive regulation of vasodilation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051346	negative regulation of hydrolase activity
GO:0051612	negative regulation of serotonin uptake
GO:0051926	negative regulation of calcium ion transport
GO:0055114	oxidation-reduction process
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0016529	sarcoplasmic reticulum
GO:0042383	sarcolemma
GO:0043197	dendritic spine
GO:0045121	membrane raft
GO:0045202	synapse