InnateDB Protein
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IDBP-195058.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Gli1
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Protein Name
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GLI-Kruppel family member GLI1
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Synonyms
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AV235269; Zfp-5; Zfp5;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000026474
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InnateDB Gene
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IDBG-195056 (Gli1)
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Protein Structure
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Function |
Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1 (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
19 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:95727
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
P47806
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PhosphoSite |
PhosphoSite-P47806
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TrEMBL |
D4Q8I4
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UniProt Splice Variant |
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Entrez Gene |
14632
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UniGene |
Mm.391450
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RefSeq |
NP_034426
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MGI ID |
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MGI Symbol |
Gli1
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OMIM |
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CCDS |
CCDS24238
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HPRD |
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IMGT |
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EMBL |
AB025922
AB234616
AB234617
AC114678
AF026305
BC131650
CH466578
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GenPept |
AAC09169
AAI31651
BAA85004
BAJ05821
BAJ05822
EDL24501
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