Version 5.4
Mus musculus Protein: Nhedc2
Summary
InnateDB Protein IDBP-195346.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nhedc2
Protein Name Na+/H+ exchanger domain containing 2
Synonyms C80638; nha-oc; NHA2; nhaoc; NHE10; Nhedc2;
Species Mus musculus
Ensembl Protein ENSMUSP00000060640
InnateDB Gene IDBG-195344 (Nhedc2)
Protein Structure
UniProt Annotation
Function Electroneutral exchange of protons for Na(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity. {ECO:0000269PubMed:17988971}.
Subcellular Localization Mitochondrion membrane {ECO:0000269PubMed:17988971}; Multi-pass membrane protein {ECO:0000269PubMed:17988971}.
Disease Associations
Tissue Specificity Detected in calvaria, jaw bone, around tooth buds, in mandible, maxilla, occipital bone, clavicle and femur. Not detectable in the other tissues tested. {ECO:0000269PubMed:17698421}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015299 solute:proton antiporter activity
Biological Process
GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID MGI:2140077
InterPro IPR006153 Cation/H+ exchanger
PFAM PF00999
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5BKR2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 97086
UniGene Mm.441764
RefSeq NP_849208
MGI ID
MGI Symbol Slc9b2
OMIM
CCDS CCDS17854
HPRD
IMGT
EMBL AC104874 AK029417 AK039655 BC090977
GenPept AAH90977 BAC26441 BAC30408

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca