Version 5.4
Mus musculus Gene: Nhedc2
Summary
InnateDB Gene IDBG-195344.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nhedc2
Gene Name Na+/H+ exchanger domain containing 2
Synonyms C80638; nha-oc; NHA2; nhaoc; NHE10; Nhedc2
Species Mus musculus
Ensembl Gene ENSMUSG00000037994
Encoded Proteins
IDBP-195346
Na+/H+ exchanger domain containing 2
IDBP-541710
Na+/H+ exchanger domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164038:
Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:135307700-135342767
Strand Forward strand
Band G3
Transcripts
ENSMUST00000051849 ENSMUSP00000060640
ENSMUST00000145195 ENSMUSP00000123083
ENSMUST00000126034
ENSMUST00000149655
ENSMUST00000132405
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015299 solute:proton antiporter activity
Biological Process
GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164038
View Gene Order
ENSBTAG00000040088
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q5BKR2
TrEMBL
UniProt Splice Variant
Entrez Gene 97086
UniGene Mm.441764
RefSeq NM_178877 XM_006502398 XM_006502399
OMIM
CCDS CCDS17854
HPRD
IMGT
MGI ID MGI:2140077
MGI Symbol Slc9b2
EMBL AC104874 AK029417 AK039655 BC090977
GenPept AAH90977 BAC26441 BAC30408
RNA Seq Atlas 97086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca