InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arid1a

Summary

InnateDB Protein

IDBP-195349.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arid1a

Protein Name

AT rich interactive domain 1A (SWI-like)

Synonyms

1110030E03Rik; BAF250a; Osa1; Smarcf1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008024

InnateDB Gene

IDBG-195347 (Arid1a)

Protein Structure

UniProt Annotation

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. {ECO:0000250, ECO:0000269PubMed:17640523}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00355}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed at high levels in the testis. {ECO:0000269PubMed:11318604}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005488	binding
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0031491	nucleosome binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001843	neural tube closure
GO:0003205	cardiac chamber development
GO:0003408	optic cup formation involved in camera-type eye development
GO:0006325	chromatin organization
GO:0006337	nucleosome disassembly
GO:0006351	transcription, DNA-templated
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0030900	forebrain development
GO:0042921	glucocorticoid receptor signaling pathway
GO:0043044	ATP-dependent chromatin remodeling
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060674	placenta blood vessel development