Version 5.4
Mus musculus Gene: Arid1a
Summary
InnateDB Gene IDBG-195347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arid1a
Gene Name AT rich interactive domain 1A (SWI-like)
Synonyms 1110030E03Rik; BAF250a; Osa1; Smarcf1
Species Mus musculus
Ensembl Gene ENSMUSG00000007880
Encoded Proteins
IDBP-195349
AT rich interactive domain 1A (SWI-like)
IDBP-269895
AT rich interactive domain 1A (SWI-like)
IDBP-535598
AT rich interactive domain 1A (SWI-like)
IDBP-627976
AT rich interactive domain 1A (SWI-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117713:
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:133679008-133756769
Strand Reverse strand
Band D2.3
Transcripts
ENSMUST00000008024 ENSMUSP00000008024
ENSMUST00000105897 ENSMUSP00000101517
ENSMUST00000145664 ENSMUSP00000122354
ENSMUST00000138473
ENSMUST00000139709 ENSMUSP00000131950
ENSMUST00000168582
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005488 binding
GO:0005515 protein binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0031491 nucleosome binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001843 neural tube closure
GO:0003205 cardiac chamber development
GO:0003408 optic cup formation involved in camera-type eye development
GO:0006325 chromatin organization
GO:0006337 nucleosome disassembly
GO:0006351 transcription, DNA-templated
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0030900 forebrain development
GO:0042921 glucocorticoid receptor signaling pathway
GO:0043044 ATP-dependent chromatin remodeling
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060674 placenta blood vessel development
Cellular Component
GO:0000790 nuclear chromatin
GO:0005622 intracellular
GO:0005634 nucleus
GO:0016514 SWI/SNF complex
GO:0071564 npBAF complex
GO:0071565 nBAF complex
GO:0090544 BAF-type complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117713
View Gene Order
ENSBTAG00000001024
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_244207
RMTs methylate histone arginines pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.22478 Mm.470926 Mm.473166
RefSeq NM_001080819 XM_006539325 XM_006539326 XM_006539327
OMIM
CCDS CCDS38908
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca