Version 5.4
Mus musculus Protein: Kif18a
Summary
InnateDB Protein IDBP-195466.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kif18a
Protein Name kinesin family member 18A
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000028527
InnateDB Gene IDBG-195464 (Kif18a)
Protein Structure
UniProt Annotation
Function Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression (By similarity). {ECO:0000250}.
Subcellular Localization Cell projection, ruffle {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0008574 plus-end-directed microtubule motor activity
GO:0043130 ubiquitin binding
GO:0051010 microtubule plus-end binding
GO:0070463 tubulin-dependent ATPase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0007018 microtubule-based movement
GO:0007019 microtubule depolymerization
GO:0007080 mitotic metaphase plate congression
GO:0008152 metabolic process
GO:0015031 protein transport
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005828 kinetochore microtubule
GO:0005871 kinesin complex
GO:0005901 caveola
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID MGI:2446977
InterPro IPR001752 Kinesin, motor domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00225
PRINTS PR00380
PIRSF
SMART SM00129
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91WD7
PhosphoSite PhosphoSite-Q91WD7
TrEMBL Q8BZ45
UniProt Splice Variant
Entrez Gene 228421
UniGene Mm.274086
RefSeq NP_647464
MGI ID
MGI Symbol Kif18a
OMIM
CCDS CCDS16507
HPRD
IMGT
EMBL AK036722 AK044795 AK164649 BC016095
GenPept AAH16095 BAC29551 BAC32095 BAE37860

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca