InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnaaf1

Summary

InnateDB Protein

IDBP-195574.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnaaf1

Protein Name

leucine rich repeat containing 50

Synonyms

4930457P18Rik; Lrrc50;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090790

InnateDB Gene

IDBG-195572 (Dnaaf1)

Protein Structure

UniProt Annotation

Function

Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity). {ECO:0000250}.

Subcellular Localization

Cell projection, cilium {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0045502	dynein binding

Biological Process

GO:0001947	heart looping
GO:0003341	cilium movement
GO:0003356	regulation of cilium beat frequency
GO:0030324	lung development
GO:0035469	determination of pancreatic left/right asymmetry
GO:0036158	outer dynein arm assembly
GO:0036159	inner dynein arm assembly
GO:0044458	motile cilium assembly
GO:0060271	cilium morphogenesis
GO:0060972	left/right pattern formation
GO:0070286	axonemal dynein complex assembly
GO:0071907	determination of digestive tract left/right asymmetry
GO:0071910	determination of liver left/right asymmetry