Version 5.4
Mus musculus Gene: Dnaaf1
Summary
InnateDB Gene IDBG-195572.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dnaaf1
Gene Name dynein, axonemal assembly factor 1
Synonyms 4930457P18Rik; Lrrc50
Species Mus musculus
Ensembl Gene ENSMUSG00000031831
Encoded Proteins
IDBP-195574
leucine rich repeat containing 50
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154099:
The protein encoded by this gene is cilium-specific and is required for the stability of the ciliary architecture. It is involved in the regulation of microtubule-based cilia and actin-based brush border microvilli. Mutations in this gene are associated with primary ciliary dyskinesia-13.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:119575235-119598454
Strand Forward strand
Band E1
Transcripts
ENSMUST00000093100 ENSMUSP00000090790
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0045502 dynein binding
Biological Process
GO:0001947 heart looping
GO:0003341 cilium movement
GO:0003356 regulation of cilium beat frequency
GO:0030324 lung development
GO:0035469 determination of pancreatic left/right asymmetry
GO:0036158 outer dynein arm assembly
GO:0036159 inner dynein arm assembly
GO:0044458 motile cilium assembly
GO:0060271 cilium morphogenesis
GO:0060972 left/right pattern formation
GO:0070286 axonemal dynein complex assembly
GO:0071907 determination of digestive tract left/right asymmetry
GO:0071910 determination of liver left/right asymmetry
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005930 axoneme
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154099
View Gene Order
ENSBTAG00000018771
Not yet available
Cross-References
SwissProt Q9D2H9
TrEMBL
UniProt Splice Variant
Entrez Gene 68270
UniGene Mm.475128
RefSeq NM_026648
OMIM
CCDS CCDS22709
HPRD
IMGT
MGI ID MGI:1915520
MGI Symbol Dnaaf1
EMBL AK006656 AK019633 BC050751
GenPept AAH50751 BAB24692 BAB31818
RNA Seq Atlas 68270

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca