InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptprm

Summary

InnateDB Protein

IDBP-195583.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptprm

Protein Name

protein tyrosine phosphatase, receptor type, M

Synonyms

mKIAA4044; RPTPmu;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045603

InnateDB Gene

IDBG-195581 (Ptprm)

Protein Structure

UniProt Annotation

Function

Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Most abundant in lung, less in brain and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0042802	identical protein binding
GO:0045296	cadherin binding

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0006470	protein dephosphorylation
GO:0007156	homophilic cell adhesion
GO:0007165	signal transduction
GO:0010596	negative regulation of endothelial cell migration
GO:0010842	retina layer formation
GO:0016311	dephosphorylation
GO:0016525	negative regulation of angiogenesis
GO:0031175	neuron projection development
GO:0031290	retinal ganglion cell axon guidance
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042493	response to drug
GO:0045909	positive regulation of vasodilation

Cellular Component

GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0005913	cell-cell adherens junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030027	lamellipodium
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:102694

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR000998 MAM domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR013151 Immunoglobulin
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00629
PF00041
PF01108
PF00047

PRINTS

PR00700
PR00020

PIRSF

SMART

SM00194
SM00137
SM00404
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt