InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptprm

Summary

InnateDB Gene

IDBG-195581.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptprm

Gene Name

protein tyrosine phosphatase, receptor type, M

Synonyms

mKIAA4044; RPTPmu

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033278

Encoded Proteins

IDBP-195583

protein tyrosine phosphatase, receptor type, M

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173482:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:66666848-67354459

Strand

Reverse strand

Band

E1.1

Transcripts

ENSMUST00000037974

ENSMUSP00000045603

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0042802	identical protein binding
GO:0045296	cadherin binding

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0006470	protein dephosphorylation
GO:0007156	homophilic cell adhesion
GO:0007165	signal transduction
GO:0010596	negative regulation of endothelial cell migration
GO:0010842	retina layer formation
GO:0016311	dephosphorylation
GO:0016525	negative regulation of angiogenesis
GO:0031175	neuron projection development
GO:0031290	retinal ganglion cell axon guidance
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042493	response to drug
GO:0045909	positive regulation of vasodilation

Cellular Component

GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0005913	cell-cell adherens junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030027	lamellipodium
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000173482

View Gene Order

ENSBTAG00000024015

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04514

Cell adhesion molecules (CAMs) pathway

mmu04520

Adherens junction pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04520

Adherens junction pathway

INOH

PID NCI

nectin_pathway

Nectin adhesion pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.311809

RefSeq

NM_008984

OMIM

CCDS

CCDS28948

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas