InnateDB Protein
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IDBP-195700.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slc5a12
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Protein Name
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solute carrier family 5 (sodium/glucose cotransporter), member 12
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000047340
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InnateDB Gene
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IDBG-195698 (Slc5a12)
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Protein Structure
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Function |
Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate. {ECO:0000269PubMed:16104846, ECO:0000269PubMed:16873376}.
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Subcellular Localization |
Apical cell membrane {ECO:0000269PubMed:16873376, ECO:0000269PubMed:17692818}; Multi- pass membrane protein {ECO:0000269PubMed:16873376, ECO:0000269PubMed:17692818}. Note=Detected at the brush border membrane of the kidney. Colocalizes with vimentin in Mueller cells.
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Disease Associations |
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Tissue Specificity |
Expressed in the cortical region of the kidney corresponding to the proximal tubule. Expressed in Mueller cells of the inner retina (at protein level). Isoform 1 is expressed in the retina, kidney, small intestine and skeletal muscle. Isoform 2 is not detected in the kidney, small intestine and skeletal muscle. In the kidney, expressed predominantly in tubular epithelial cells of the cortical region and in the convoluted portions of the proximal tubule (pars convoluta). In the small intestine, its expression is highest in the proximal part and gradually decreased towards the distal end. Expressed in the neural retina. Not detected in the caecum and colon. {ECO:0000269PubMed:16104846, ECO:0000269PubMed:16873376, ECO:0000269PubMed:17591909, ECO:0000269PubMed:17692818}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2138890
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InterPro |
IPR001734
Sodium/solute symporter
IPR019900
Sodium/solute symporter, subgroup
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PFAM |
PF00474
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q49B93
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PhosphoSite |
PhosphoSite-Q49B93
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
241612
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UniGene |
Mm.277148
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RefSeq |
NP_001003915
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MGI ID |
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MGI Symbol |
Slc5a12
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OMIM |
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CCDS |
CCDS16512
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HPRD |
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IMGT |
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EMBL |
AF529222
AK144004
AK165419
AL732495
AY964639
BC121791
BX005257
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GenPept |
AAI21792
AAQ09530
AAY32930
BAE25658
BAE38174
CAM26858
CAM26859
CAM27818
CAM27819
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