InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nr5a2

Summary

InnateDB Protein

IDBP-195759.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr5a2

Protein Name

nuclear receptor subfamily 5, group A, member 2

Synonyms

AU020803; D1Ertd308e; Ftf; LRH-1; UF2-H3B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027649

InnateDB Gene

IDBG-195757 (Nr5a2)

Protein Structure

UniProt Annotation

Function

Binds to promoters containing the sequence element 5'- AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008206	bile acid metabolic process
GO:0031018	endocrine pancreas development
GO:0042127	regulation of cell proliferation
GO:0042632	cholesterol homeostasis
GO:0043401	steroid hormone mediated signaling pathway
GO:0045070	positive regulation of viral genome replication
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1346834

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR016355 Steroidogenic factor 1

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398

PIRSF

PIRSF002530

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References