Version 5.4
Mus musculus Protein: Sec11a
Summary
InnateDB Protein IDBP-195778.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sec11a
Protein Name SEC11 homolog A (S. cerevisiae)
Synonyms 1810012E07Rik; 18kDa; Sec11l1; sid2895; Sid2895p; Spc18;
Species Mus musculus
Ensembl Protein ENSMUSP00000026818
InnateDB Gene IDBG-195776 (Sec11a)
Protein Structure
UniProt Annotation
Function Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.
Subcellular Localization Microsome membrane {ECO:0000250}; Single- pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006465 signal peptide processing
GO:0006508 proteolysis
GO:0008150 biological_process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1929464
InterPro IPR001733 Peptidase S26B, eukaryotic signal peptidase
IPR015927 Peptidase S24/S26A/S26B/S26C
IPR019759 Peptidase S24/S26A/S26B
PFAM PF00717
PRINTS PR00728
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R0P6
PhosphoSite PhosphoSite-Q9R0P6
TrEMBL Q6PET3
UniProt Splice Variant
Entrez Gene 56529
UniGene Mm.43760
RefSeq NP_064335
MGI ID
MGI Symbol Sec11a
OMIM
CCDS CCDS21401
HPRD
IMGT
EMBL AB025405 AK007449 BC010484 BC057885
GenPept AAH10484 AAH57885 BAA84690 BAB25044

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca