InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plcz1

Summary

InnateDB Protein

IDBP-195784.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plcz1

Protein Name

phospholipase C, zeta 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032356

InnateDB Gene

IDBG-195782 (Plcz1)

Protein Structure

UniProt Annotation

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250UniProtKB:Q86YW0, ECO:0000269PubMed:12117804, ECO:0000269PubMed:14701816, ECO:0000269PubMed:15159452, ECO:0000269PubMed:15385165, ECO:0000269PubMed:15790568, ECO:0000269PubMed:16854985, ECO:0000269PubMed:17933795, ECO:0000269PubMed:18028898, ECO:0000269PubMed:18322275, ECO:0000305}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14701816, ECO:0000269PubMed:15159452, ECO:0000269PubMed:15385165, ECO:0000269PubMed:15809052, ECO:0000269PubMed:18322275}. Cytoplasm, perinuclear region {ECO:0000269PubMed:14701816, ECO:0000269PubMed:15159452, ECO:0000269PubMed:15385165, ECO:0000269PubMed:15809052, ECO:0000269PubMed:18322275}. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronuclei at interphase following meiosis and mitosis. {ECO:0000269PubMed:14701816, ECO:0000269PubMed:15159452, ECO:0000269PubMed:15385165, ECO:0000269PubMed:15809052, ECO:0000269PubMed:18322275}.

Disease Associations

Tissue Specificity

Highly expressed in postpuberal testis, where expression is sperm cell-specific. Also expressed in brain of both sexes. {ECO:0000269PubMed:12117804}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006816	calcium ion transport
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007343	egg activation
GO:0008152	metabolic process
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:2150308

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR002048 EF-hand domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM