InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Plcz1

Summary

InnateDB Gene

IDBG-195782.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plcz1

Gene Name

phospholipase C, zeta 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030230

Encoded Proteins

IDBP-195784

phospholipase C, zeta 1

IDBP-539516

phospholipase C, zeta 1

IDBP-536521

phospholipase C, zeta 1

IDBP-534662

phospholipase C, zeta 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139151:
The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:139989676-140041457

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032356	ENSMUSP00000032356
ENSMUST00000137148	ENSMUSP00000121908
ENSMUST00000129986	ENSMUSP00000119121
ENSMUST00000149931	ENSMUSP00000117043

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006816	calcium ion transport
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007343	egg activation
GO:0008152	metabolic process
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction