InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: H2afz

Summary

InnateDB Protein

IDBP-195975.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2afz

Protein Name

H2A histone family, member Z

Synonyms

H2A.Z; H2a.z-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036907

InnateDB Gene

IDBG-195973 (H2afz)

Protein Structure

UniProt Annotation

Function

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Essential for early development. {ECO:0000269PubMed:11516949, ECO:0000269PubMed:15195148, ECO:0000269PubMed:15546624}.

Subcellular Localization

Nucleus. Chromosome. Note=Enriched in constitutive heterochromatin. Absent from facultative heterochromatin of the inactive X chromosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	15 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0031490	chromatin DNA binding
GO:0031492	nucleosomal DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006334	nucleosome assembly
GO:0007275	multicellular organismal development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071392	cellular response to estradiol stimulus