Mus musculus Gene: H2afz | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-195973.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | H2afz | ||||||||||||||||||||||
Gene Name | H2A histone family, member Z | ||||||||||||||||||||||
Synonyms | H2A.Z; H2a.z-1 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000037894 | ||||||||||||||||||||||
Encoded Proteins |
H2A histone family, member Z
H2A histone family, member Z
H2A histone family, member Z
H2A histone family, member Z
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164032:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 3:137864487-137866922 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | G3 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Meiotic Recombination pathway
Meiotic Synapsis pathway
RNA Polymerase I Transcription pathway
Oxidative Stress Induced Senescence pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Mus musculus biological processes pathway
Cell Cycle, Mitotic pathway
NoRC negatively regulates rRNA expression pathway
Chromatin organization pathway
Disease pathway
Chromosome Maintenance pathway
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
Cellular responses to stress pathway
Amyloids pathway
RNA Polymerase I Promoter Opening pathway
DNA Damage/Telomere Stress Induced Senescence pathway
PRC2 methylates histones and DNA pathway
Meiotic synapsis pathway
Telomere Maintenance pathway
Cell Cycle pathway
NoRC negatively regulates rRNA expression pathway
M Phase pathway
Condensation of Prophase Chromosomes pathway
Chromatin modifying enzymes pathway
formation of the beta-catenin:TCF transactivating complex pathway
Cellular Senescence pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Epigenetic regulation of gene expression pathway
Transcriptional regulation by small RNAs pathway
Packaging Of Telomere Ends pathway
TCF dependent signaling in response to WNT pathway
SIRT1 negatively regulates rRNA Expression pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Gene Expression pathway
DNA methylation pathway
Negative epigenetic regulation of rRNA expression pathway
Nucleosome assembly pathway
Deposition of new CENPA-containing nucleosomes at the centromere pathway
Regulatory RNA pathways pathway
RMTs methylate histone arginines pathway
Mitotic Prophase pathway
Signal Transduction pathway
Meiosis pathway
Meiotic recombination pathway
RNA Polymerase I Promoter Clearance pathway
RNA Polymerase I Chain Elongation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
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KEGG |
Systemic lupus erythematosus pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Meiotic synapsis pathway
Deposition of new CENPA-containing nucleosomes at the centromere pathway
Packaging Of Telomere Ends pathway
Amyloids pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Promoter Opening pathway
Meiotic recombination pathway
Cellular responses to stress pathway
PRC2 methylates histones and DNA pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNA Polymerase I Transcription pathway
Signaling by WNT in cancer pathway
Condensation of Prophase Chromosomes pathway
Signaling by Wnt pathway
Chromosome Maintenance pathway
Nucleosome assembly pathway
Transcriptional regulation by small RNAs pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Telomere Maintenance pathway
Signal Transduction pathway
SIRT1 negatively regulates rRNA Expression pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
DNA methylation pathway
M Phase pathway
Cellular Senescence pathway
TCF dependent signaling in response to WNT pathway
Chromatin organization pathway
Mitotic Prophase pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Meiosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Oxidative Stress Induced Senescence pathway
Gene Expression pathway
Disease pathway
Negative epigenetic regulation of rRNA expression pathway
Regulatory RNA pathways pathway
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KEGG |
Systemic lupus erythematosus pathway
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INOH | |||||||||||||||||||||||
PID NCI |
C-MYB transcription factor network
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.490507 | ||||||||||||||||||||||
RefSeq | NM_016750 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS38647 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||