Mus musculus Protein: Nek7 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-196025.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Nek7 | ||||||||||||||
Protein Name | NIMA (never in mitosis gene a)-related expressed kinase 7 | ||||||||||||||
Synonyms | 2810460C19Rik; AU020186; | ||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000027642 | ||||||||||||||
InnateDB Gene | IDBG-196023 (Nek7) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. {ECO:0000269PubMed:20473324}. | ||||||||||||||
Subcellular Localization | Nucleus {ECO:0000250}. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (By similarity). {ECO:0000250}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | |||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:1890645 | ||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||
SMART |
SM00220
SM00219 |
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q9ES74 | ||||||||||||||
PhosphoSite | PhosphoSite-Q9ES74 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 59125 | ||||||||||||||
UniGene | Mm.474125 | ||||||||||||||
RefSeq | NP_067618 | ||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Nek7 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS15332 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AF217650 AK035502 AK088173 AK149308 BC037697 | ||||||||||||||
GenPept | AAG16652 AAH37697 BAC29080 BAC40190 BAE28804 | ||||||||||||||