Version 5.4
Mus musculus Protein: Dapp1
Summary
InnateDB Protein IDBP-196061.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dapp1
Protein Name dual adaptor for phosphotyrosine and 3-phosphoinositides 1
Synonyms Bam32;
Species Mus musculus
Ensembl Protein ENSMUSP00000029806
InnateDB Gene IDBG-196059 (Dapp1)
Protein Structure
UniProt Annotation
Function May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Membrane-associated after cell stimulation leading to its translocation. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0035014 phosphatidylinositol 3-kinase regulator activity
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
Biological Process
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
Cellular Component
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
Protein Structure and Domains
PDB ID MGI:1347063
InterPro IPR000980 SH2 domain
IPR001720 PI3 kinase, P85 regulatory subunit
IPR001849 Pleckstrin homology domain
PFAM PF00017
PF14633
PF00169
PRINTS PR00401
PR00678
PIRSF
SMART SM00252
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QXT1
PhosphoSite PhosphoSite-Q9QXT1
TrEMBL Q3UK44
UniProt Splice Variant
Entrez Gene 26377
UniGene Mm.470427
RefSeq NP_036062
MGI ID
MGI Symbol Dapp1
OMIM
CCDS CCDS17864
HPRD
IMGT
EMBL AF163255 AF186023 AK146180 BC014759 CH466532
GenPept AAD49698 AAF14579 AAH14759 BAE26958 EDL12112

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca