InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rasal1

Summary

InnateDB Protein

IDBP-196098.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasal1

Protein Name

RAS protein activator like 1 (GAP1 like)

Synonyms

MRASAL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031606

InnateDB Gene

IDBG-196096 (Rasal1)

Protein Structure

UniProt Annotation

Function

Probable inhibitory regulator of the Ras-cyclic AMP pathway.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane

Protein Structure and Domains

PDB ID

MGI:1330842

InterPro

IPR000008 C2 domain
IPR001562 Zinc finger, Btk motif
IPR001849 Pleckstrin homology domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein

PFAM

PF00168
PF00779
PF00169
PF00616

PRINTS

PR00360
PR00402

PIRSF

SMART

SM00239
SM00107
SM00233
SM00323

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt