InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rasal1

Summary

InnateDB Gene

IDBG-196096.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasal1

Gene Name

RAS protein activator like 1 (GAP1 like)

Synonyms

MRASAL

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029602

Encoded Proteins

IDBP-196098

RAS protein activator like 1 (GAP1 like)

IDBP-541507

RAS protein activator like 1 (GAP1 like)

IDBP-541239

RAS protein activator like 1 (GAP1 like)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111344:
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:120648812-120679597

Strand

Forward strand

Band

Transcripts

ENSMUST00000031606	ENSMUSP00000031606
ENSMUST00000125804	ENSMUSP00000119913
ENSMUST00000156722	ENSMUSP00000123266
ENSMUST00000148695
ENSMUST00000154759

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000111344

View Gene Order

ENSBTAG00000016739

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

ras_pathway

Regulation of Ras family activation

Cross-References

SwissProt

Q9Z268

TrEMBL

D3Z7V8 Q3TQ19

UniProt Splice Variant

Entrez Gene

19415

UniGene

Mm.41209 Mm.413857

RefSeq

NM_013832 XM_006530208 XM_006530210 XM_006530212 XM_006530213 NM_001281999 XM_006530209

OMIM

CCDS

CCDS19623

HPRD

IMGT

MGI ID

MGI:1330842

MGI Symbol

Rasal1

EMBL

AC125183 AF086714 AK163980 BC005418 CH466529

GenPept

AAD09007 AAH05418 BAE37566 EDL19757

RNA Seq Atlas

19415