InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Naca

Summary

InnateDB Protein

IDBP-196406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Naca

Protein Name

nascent polypeptide-associated complex alpha polypeptide

Synonyms

AL022831; AL024382; Gm1878; mKIAA0363; skNAC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073532

InnateDB Gene

IDBG-196404 (Naca)

Protein Structure

UniProt Annotation

Function

Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). Isoform 1 and isoform 2 appear to bind DNA and play roles in transcription. Isoform 1 may function as a specific coactivator for JUN, acting to stabilize the interaction of JUN homodimers with promoter elements. {ECO:0000250, ECO:0000269PubMed:15299025, ECO:0000269PubMed:15831452, ECO:0000269PubMed:8698236, ECO:0000269PubMed:9488445, ECO:0000269PubMed:9488446}.

Subcellular Localization

Cytoplasm. Nucleus. Note=The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 appears to be ubiquitously expressed. {ECO:0000269PubMed:10224091, ECO:0000269PubMed:8698236, ECO:0000269PubMed:9877153}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0017025	TBP-class protein binding

Biological Process

GO:0003231	cardiac ventricle development
GO:0006351	transcription, DNA-templated
GO:0010664	negative regulation of striated muscle cell apoptotic process
GO:0015031	protein transport
GO:0043403	skeletal muscle tissue regeneration
GO:0048633	positive regulation of skeletal muscle tissue growth
GO:0048742	regulation of skeletal muscle fiber development
GO:0051451	myoblast migration
GO:0061384	heart trabecula morphogenesis
GO:1901227	negative regulation of transcription from RNA polymerase II promoter involved in heart development
GO:1901228	positive regulation of transcription from RNA polymerase II promoter involved in heart development
GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis