InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Naca

Summary

InnateDB Gene

IDBG-196404.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Naca

Gene Name

nascent polypeptide-associated complex alpha polypeptide

Synonyms

AL022831; AL024382; Gm1878; mKIAA0363; skNAC

Species

Mus musculus

Ensembl Gene

ENSMUSG00000061315

Encoded Proteins

IDBP-196406

nascent polypeptide-associated complex alpha polypeptide

IDBP-196408

nascent polypeptide-associated complex alpha polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196531:
The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:128035346-128048637

Strand

Forward strand

Band

Transcripts

ENSMUST00000073868	ENSMUSP00000073532
ENSMUST00000092048	ENSMUSP00000089680

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0017025	TBP-class protein binding

Biological Process

GO:0003231	cardiac ventricle development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0010664	negative regulation of striated muscle cell apoptotic process
GO:0015031	protein transport
GO:0043403	skeletal muscle tissue regeneration
GO:0048633	positive regulation of skeletal muscle tissue growth
GO:0048742	regulation of skeletal muscle fiber development
GO:0051451	myoblast migration
GO:0061384	heart trabecula morphogenesis
GO:1901227	negative regulation of transcription from RNA polymerase II promoter involved in heart development
GO:1901228	positive regulation of transcription from RNA polymerase II promoter involved in heart development
GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000196531

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

ilk_pathway

Integrin-linked kinase signaling

Cross-References

SwissProt

Q60817

TrEMBL

UniProt Splice Variant

Entrez Gene

17938

UniGene

Mm.3746

RefSeq

NM_001282976 NM_013608 NM_001113199 XM_006513332 XM_006513333

OMIM

CCDS

CCDS24258 CCDS48723

HPRD

IMGT

MGI ID

MGI:106095

MGI Symbol

Naca

EMBL

AK146197 AK151928 AK161678 AK168023 AK168169 AK168607 AK169432 AK169435 BC029830 BC083340 BC099375 U22151 U48363

GenPept

AAB18733 AAB80961 AAH29830 AAH83340 AAH99375 BAE26971 BAE30804 BAE36526 BAE40008 BAE40130 BAE40474 BAE41173 BAE41176

RNA Seq Atlas

17938