Version 5.4
Mus musculus Protein: Naca
Summary
InnateDB Protein IDBP-196408.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Naca
Protein Name nascent polypeptide-associated complex alpha polypeptide
Synonyms AL022831; AL024382; Gm1878; mKIAA0363; skNAC;
Species Mus musculus
Ensembl Protein ENSMUSP00000089680
InnateDB Gene IDBG-196404 (Naca)
Protein Structure
UniProt Annotation
Function Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres. {ECO:0000269PubMed:21071677, ECO:0000269PubMed:23662692, ECO:0000269PubMed:8698236}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12011100}. Nucleus {ECO:0000269PubMed:12011100}.
Disease Associations
Tissue Specificity Specifically expressed in heart and skeletal muscle: it is present in differentiated myotubes but not in myoblasts. {ECO:0000269PubMed:8698236}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0017025 TBP-class protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006810 transport
GO:0051451 myoblast migration
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:106095
InterPro IPR002715 Nascent polypeptide-associated complex NAC domain
IPR009060 UBA-like
PFAM PF01849
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70670
PhosphoSite PhosphoSite-P70670
TrEMBL
UniProt Splice Variant
Entrez Gene 17938
UniGene Mm.3746
RefSeq NP_001106670
MGI ID
MGI Symbol Naca
OMIM
CCDS CCDS48723
HPRD
IMGT
EMBL AC131120 U48363 U48364
GenPept AAB18732 AAB18734

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca