InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc13a5

Summary

InnateDB Protein

IDBP-196440.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc13a5

Protein Name

solute carrier family 13 (sodium-dependent citrate transporter), member 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021161

InnateDB Gene

IDBG-196438 (Slc13a5)

Protein Structure

UniProt Annotation

Function

High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005343	organic acid:sodium symporter activity
GO:0015137	citrate transmembrane transporter activity
GO:0015141	succinate transmembrane transporter activity
GO:0015142	tricarboxylic acid transmembrane transporter activity
GO:0017153	sodium:dicarboxylate symporter activity

Biological Process

GO:0006814	sodium ion transport
GO:0006842	tricarboxylic acid transport
GO:0015744	succinate transport
GO:0015746	citrate transport
GO:0035674	tricarboxylic acid transmembrane transport
GO:0055085	transmembrane transport
GO:0071422	succinate transmembrane transport