InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myl12b

Summary

InnateDB Protein

IDBP-196465.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myl12b

Protein Name

myosin, light chain 12B, regulatory

Synonyms

1500001M02Rik; C77744; Mylc2b; RLC-B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042364

InnateDB Gene

IDBG-196463 (Myl12b)

Protein Structure

UniProt Annotation

Function

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0008360

regulation of cell shape

Cellular Component

GO:0001725	stress fiber
GO:0016460	myosin II complex
GO:0030018	Z disc
GO:0043234	protein complex
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome